@article{JGO1066,
author = {Timothy A. Platz and Steven J. Nurkin and Mei Ka Fong and Adrienne Groman and Leayn Flaherty and Usha Malhotra and Charles M. LeVea and Sai Yendamuri and Graham W. Warren and Hector R. Nava and Kilian S. May},
title = {Neoadjuvant chemoradiotherapy for esophageal/ gastroesophageal carcinoma},
journal = {Journal of Gastrointestinal Oncology},
volume = {4},
number = {2},
year = {2013},
keywords = {},
abstract = {Background: Esophageal/gastroesophageal junction (GEJ) adenocarcinoma is increasingly treated with trimodality therapy. We present our experience using carboplatin/paclitaxel and radiotherapy followed by surgery.
Methods: Consecutive patients with distal esophageal/GEJ adenocarcinoma (≥T2 or N+) treated from July 2010 to October 2011 were identified. Treatment included neoadjuvant carboplatin/ paclitaxel with concurrent radiotherapy (CRT) to 50.4 Gy using an IMRT technique and then Ivor Lewis esophagogastrectomy (ILE). PET/CT was performed prior to and after CRT. Patient/treatment characteristics and tumor response were analyzed.
Results: Over this timeframe, 16 patients completed trimodality therapy. All were male, median age of 60 years (45-72 years). All tumors were grade 2-3 with mean tumor length of 4.4 cm (1-9 cm). A median of 6 cycles (5-9 cycles) neoadjuvant carboplatin/paclitaxel were administered. Average time from diagnosis to CRT completion was 76 days (44-141 days) and 60 days (35-92 days) from CRT end to surgery. Neoadjuvant CRT was well tolerated with mean weight loss of 3.9 kg. All pts had R0 resections. No anastomotic leaks or perioperative mortality occurred. Mean hospital stay was 13 days (8-28 days). Pathologic complete response (pCR) was seen in 38% of patients, microscopic residual disease (isolated tumor cells or },
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/1066}
}