@article{JGO1399,
author = {Ashwini Gowryshankar and Vinayak Nagaraja and Guy D. Eslick},
title = {HER2 status in Barrett’s Esophagus & Esophageal Cancer: a meta analysis},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {1},
year = {2013},
keywords = {},
abstract = {Background: The oncogenic potential of the Human Epidermal Growth Factor Receptor 2 (HER2) is well known in the context of breast cancer however; its relationship with the development of Barrett’s Esophagus (BE) and Esophageal Cancer (EC) is unclear. The aim of this meta-analysis was to determine the overall prevalence and survival of HER2+ in BE & EC.
Patients and methods: Several databases were searched including article reference lists. Inclusion criteria required that studies measured HER2 positivity in subjects with BE or EC.
Results: 33 studies were included in the meta-analysis (10 BE & 23 EC studies). The prevalence of HER2+ was found to be 24% (95% CI: 15-36%) in BE and 26% (95% CI: 19-34%) in EC. Squamous cell carcinoma (SCC) had a higher ER of 32% (95% CI: 20-48%) in comparison with adenocarcinoma (ADC) with an ER of 21% (95% CI: 14-32%). Sub group analyses showed a high geographical variance, Asia was found to be the highest prevalent area with an ER 42% (95% CI: 22-64%). The difference in survival rate between groups HER2- & HER2+ was found to be 7 months.
Conclusions: Our results highlight a high prevalence of HER2+ in subjects with adenocarcinoma. HER2+ appears to decrease the survival time of EC patients.},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/1399}
}