@article{JGO16909,
author = {Carrie Luu and Ram Thapa and Katherine Woo and Domenico Coppola and Khaldoun Almhanna and Jose M. Pimiento and Dung-Tsa Chen and Daissy Dominguez Marquez and Pamela J. Hodul},
title = {Does histology really influence gastric cancer prognosis?},
journal = {Journal of Gastrointestinal Oncology},
volume = {8},
number = {6},
year = {2017},
keywords = {},
abstract = {Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival.
Methods: The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signetring cell features (n=57), and LP (n=40). LP patients had diffuse GC but also presented with circumferential infiltration of the gastric wall for at least a third of the stomach length on endoscopy or imaging. Fisher’s exact test was used to compare groups; Cox regression was used for multivariate analysis and Kaplan-Meier method for survival.
Results: Of 210 patients who underwent gastric resection, 112 (53%) were male with mean age 65.3 years (SD ±14.6 years). Intestinal GC patients were older at diagnosis but other patient demographics were similar between all groups. LP patients had a higher rate of R1 resection despite higher rates of total gastrectomy (P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/16909}
}