TY  - JOUR
AU  - Luu, Andreas Minh
AU  - Herzog, Torsten
AU  - Hoehn, Philipp
AU  - Reinacher-Schick, Anke
AU  - Munding, Johanna
AU  - Uhl, Waldemar
AU  - Braumann, Chris
PY  - 2018
TI  - FOLFIRINOX treatment leading to pathologic complete response of a locally advanced pancreatic cancer
JF  - Journal of Gastrointestinal Oncology; Vol 9, No 2 (April 16, 2018): Journal of Gastrointestinal Oncology
Y2  - 2018
KW  - 
N2  - Pancreatic cancer (PC) is a lethal disease with a poor prognosis. It is typically asymptomatic and therefore most often diagnosed at an advanced stage. A primary unresectable PC can become resectable in case of tumor regression turning palliative into neoadjuvant therapy. We present a 67-year old female patient who was diagnosed with a locally advanced adenocarcinoma of the pancreatic head. After receiving palliative intended chemotherapy with the FOLFIRINOX regimen, staging computed tomography revealed local resectability of the pancreatic head tumor. The patient underwent an uneventful total pancreatectomy. Pathohistological investigation revealed a pathologic complete response (pCR). pCR after FOLFIRINOX treatment in primary unresectable PC is extremely rare. It might enable surgical resection and can increase the survival rate.
UR  - https://jgo.amegroups.org/article/view/18727