@article{JGO19445,
author = {Vivek Verma and Adams Kusi Appiah and Tim Lautenschlaeger and Sebastian Adeberg and Charles B. Simone II and Chi Lin},
title = {Chemoradiotherapy versus chemotherapy alone for unresected intrahepatic cholangiocarcinoma: practice patterns and outcomes from the national cancer data base},
journal = {Journal of Gastrointestinal Oncology},
volume = {9},
number = {3},
year = {2018},
keywords = {},
abstract = {Background: Current guidelines recommend chemotherapy (CT) with or without radiotherapy (RT) for unresected intrahepatic cholangiocarcinoma (IC). Although there is currently lack of consensus, previous smaller studies have illustrated the efficacy of local therapy for this population. This investigation evaluated outcomes of chemoradiotherapy (CRT) versus CT alone in unresected IC using a large, contemporary national database.
Methods: The National Cancer Data Base (NCDB) was queried for primary IC cases (2004–2013) receiving CT alone or CRT. Patients undergoing resection or not receiving CT were excluded, as were those with M1 disease or unknown M classification. Logistic regression analysis ascertained factors associated with CRT administration. Kaplan-Meier analysis evaluated overall survival (OS) between both groups. Cox proportional hazards modeling assessed variables associated with OS.
Results: In total, 2,842 patients were analyzed [n=666 (23%) CRT, n=2,176 (77%) CT]. CRT was less likely delivered at community centers, in more recent time periods (2009–2013), to older patients, and in certain geographic locations. Median OS in the CRT and CT groups were 13.6 vs. 10.5 months, respectively (P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/19445}
}