@article{JGO2,
author = {Kilian May and Gary Yang and Nikhil Khushalani and Rameela Chandrasekhar and Gregory Wilding and Leayn Flaherty and Harish Malhotra and Richard Russo and John Warner and Johnny Yap and Renuka Iyer and Chukwumere Nwogu and Saikrishna Yendamuri and John Gibbs and Hector Nava and Dominick Lamonica and Charles Thomas},
title = {Association of Technetium99m MAG-3 renal scintigraphy with change in creatinine clearance following chemoradiation to the abdomen in patients with gastrointestinal malignancies},
journal = {Journal of Gastrointestinal Oncology},
volume = {1},
number = {1},
year = {2010},
keywords = {},
abstract = {Background: Information on differential renal function following abdominal chemoradiation is limited. This study evaluated the association between renal function as measured by biochemical endpoints and scintigraphy and dose volume parameters in patients with gastrointestinal malignancies.
Methods: Patients who received abdominal chemoradiation between 2002 and 2009 were identified for this study. Technetium99m MAG-3 scintigraphy and laboratory data were obtained prior to and after chemoradiation in 6 month intervals. Factors assessed included age, gender, hypertension, diabetes, and dose volume parameters. Renal function was assessed by biochemical endpoints and renal scintigraphy.
Results: Significant reductions in relative renal function of the primarily irradiated kidney and creatinine clearance were seen. Split renal function decreased from 49.75% pre-radiation to 47.74% and 41.28% at 6-12 months and >12 months post-radiation (p=0.0184). Creatinine clearance declined from 90.67ml/min pre-radiation to 82.23ml/min and 74.54ml/min at 6-12 months and >12 months post-radiation (p},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/2}
}