@article{JGO21994,
author = {Samira Mousavi and Reza Safaralizadeh and Mohammadali Hosseinpour-Feizi and Arash Azimzadeh-Isfanjani and Shahryar Hashemzadeh},
title = {Study of cofilin 1 gene expression in colorectal cancer},
journal = {Journal of Gastrointestinal Oncology},
volume = {9},
number = {5},
year = {2018},
keywords = {},
abstract = {Background: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Cofilin is a key regulatory protein in the dynamics of actin filaments. Previous studies have shown cofilin 1’s major role in cell migration process and its role in tumor cell migration and invasion. Therefore, cofilin 1 may have the potential as a novel diagnostic tumor marker in various cancers. In this study, differential expression of CFL1 in CRC tissues in comparison with adjacent non-tumor tissues was investigated and the diagnostic value of this protein in CRC was evaluated.
Methods: Synthesized cDNA from extracted RNAs of 30 patients were subjected to qRT-PCR to quantify relative expression of cofilin 1. The relationship between cofilin 1 expression and clinicopathological features of patients were studied too.
Results: The study showed significant upregulation of cofilin 1 in CRC tissue samples compared to adjacent non-tumor tissue samples (P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/21994}
}