@article{JGO2261,
author = {Jorge Arredondo and Patricia Martínez and Jorge Baixauli and Carlos Pastor and Javier Rodríguez and Fernando Pardo and Fernando Rotellar and Ana Chopitea and José Luís Hernández-Lizoáin},
title = {Analysis of surgical complications of primary tumor resection after neoadjuvant treatment in stage IV colon cancer},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {2},
year = {2014},
keywords = {},
abstract = {Purpose: Assess the surgical complications of primary tumor resection in stage IV colon cancer patients previously treated with neoadjuvant chemotherapy.
Methods: Between July 2001 and September 2010, 67 consecutive patients received preoperative chemotherapy. Clinical and surgical complications were obtained from the medical records. This study was retrospective in design.
Results: All patients were affected with liver metastasis, and 29.8% had metastasis in additional organs. Three different schemes of preoperative chemotherapy were employed, based on FOLFIRI, XELOXIRI or XELOX plus cetuximab. Eighteen patients (26.8%) reported some side effects to the chemotherapy, without contraindicating any intervention. All patients underwent colon surgery and within those, eight patients (11.9%), underwent liver surgery simultaneously. Median hospital admission was 8 [3-29] days. The perioperative complication rate was 16.2%, when the estimated physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) was 58.3%. There was not perioperative mortality, despite the mortality prediction for Portsmouth-POSSUM (P-POSSUM) being 5.07%. No differences were observed between the chemotherapy regimen (P=0.72) or the kind of the surgery—simple or combined (P=0.58).
Conclusions: Neoadjuvant chemotherapy as a systemic treatment for stage IV colon cancer does not indicate surgery contraindication nor increases postoperative morbimortality by a significant amount.},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/2261}
}