@article{JGO2273,
author = {Jorge Arredondo and Ignacio González and Jorge Baixauli and Patricia Martínez and Javier Rodríguez and Carlos Pastor and María Jesús Ribelles and Jesús Javier Sola and José Luís Hernández-Lizoain},
title = {Tumor response assessment in locally advanced colon cancer after neoadjuvant chemotherapy},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {2},
year = {2014},
keywords = {},
abstract = {Background: Preoperative chemotherapy followed by radical surgery is a novel therapeutic approach for locally advanced colon cancer (LACC). Neoadjuvant strategies require highly accurate diagnostic tests for a proper selection of candidate patients, allowing a low risk of overtreatment. This paper assesses the radiological, metabolic and pathological findings induced by preoperative oxaliplatin and fluoropyrimidinesbased chemotherapy in LACC.
Methods: Forty-four consecutive patients with a confirmed diagnosis of LACC who received neoadjuvant chemotherapy and colon surgery were included. All patients were staged at baseline and before surgery. Clinical diagnosis consisted of physical examination, endoscopy with biopsy and computed tomography (CT) scan. In selected cases, a positron emission tomography/CT (PET/CT) scan was also performed. Accuracy and correlations between CT scan findings and pathologic report was assayed for T stage, N stage and TN stage. This study is retrospective in design.
Results: After chemotherapy, a statistical significant tumor volume reduction of 62.5% was achieved by CT-scan (P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/2273}
}