@article{JGO2321,
author = {William A. Hall and Lauren E. Colbert and Dana Nickleach and Jeffrey Switchenko and Yuan Liu and Theresa Gillespie and Joseph Lipscomb and Claire Hardy and David A. Kooby and Roshan S. Prabhu and John Kauh and Jerome C. Landry},
title = {The influence of radiation therapy dose escalation on overall survival in unresectable pancreatic adenocarcinoma},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {2},
year = {2014},
keywords = {},
abstract = {Purpose: Radiation therapy (RT) dose escalation in unresectable pancreatic adenocarcinoma (PAC) remains investigational. We examined the association between total RT dose and overall survival (OS) in patients with unresectable PAC.
Methods and materials: National cancer data base (NCDB) data were obtained for patients who underwent definitive chemotherapy and RT (chemo-RT) for unresectable PAC. Univariate (UV) and multivariate (MV) survival analysis were performed along with Kaplan-Meier (KM) estimates for incremental RT dose levels.
Results: A total of 977 analyzable patients met inclusion criteria. Median tumor size was 4.0 cm (0.3-40 cm) and median RT dose was 45 Gy. Median OS was 10 months (95% CI, 9-10 months). On MV analysis RT dose },
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/2321}
}