@article{JGO2327,
author = {Alessandro Repici and Chiara Genco and Andrea Anderloni and Paola Spaggiari and Rosanna Minieri and Alessandra Carlino and Manol Jovani and Vincenzo Villanacci and Prateek Sharma and Alberto Malesci},
title = {A case of esophageal squamous cell intraepithelial neoplasia with positivity for type 16 human papillomavirus successfully treated with radiofrequency ablation},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {2},
year = {2014},
keywords = {},
abstract = {Esophageal cancer is the eight most common cancer worldwide and the sixth cause of cancer related death with squamous cell carcinoma (SCC) accounting for almost half of all esophageal cancers. Persistent human papilloma virus (HPV) infection has been suspected to play an active role in esophageal carcinogenesis but a clear association has not still been proved and no specific indications or guidelines for possible endoscopic and surgical therapeutic approaches to this clinical scenario are available. We report a case of a 62-year-old woman with histological diagnosis of high-grade intraepithelial squamous neoplasia of distal esophagus associated with cytological modifications resembling cervical HPV infection and with a positive INNO-LiPA assay for genotype 16 HPV. A single session of radiofrequency ablation (RFA) was performed on the dysplastic esophageal area with complete endoscopic eradication as confirmed by the following endoscopic, histologic and microbiologic examinations. Our report might give further strength to the hypothesis of an etiological role of HPV in selected cases of esophageal carcinogenesis and opens a discussion on the possible use of Radio Frequency Ablation as an effective and safe endoscopic treatment for both early squamous cell neoplasia and HPV esophageal colonization.},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/2327}
}