@article{JGO26210,
author = {Angelica Petrillo and Maria Maddalena Laterza and Giuseppe Tirino and Luca Pompella and Annalisa Pappalardo and Jole Ventriglia and Beatrice Savastano and Annamaria Auricchio and Michele Orditura and Fortunato Ciardiello and Gennaro Galizia and Ferdinando De Vita},
title = {Increased circulating levels of vascular endothelial growth factor C can predict outcome in resectable gastric cancer patients},
journal = {Journal of Gastrointestinal Oncology},
volume = {10},
number = {2},
year = {2018},
keywords = {},
abstract = {Background: Neoangiogenesis has proven to be a relevant pathogenetic mechanism in gastric cancer (GC) and lymphatic spread represents an important well-known prognostic factor. Vascular endothelial growth factor C (VEGF-C) plays a key role in lymphangiogenesis and its blood levels in GC patients are easily measurable. This analysis aimed to investigate the prognostic role of preoperative VEGF-C blood levels.
Methods: VEGF-C serum levels were determined by enzyme-linked immunoadsorbent assay (ELISA) in 186 patients observed at our institution from January 2004 until December 2009 and 82 healthy subjects. Statistical analyses were performed using SPSS 21.0.
Results: VEGF-C levels were significantly higher in GC patients (median: 287.4 pg/mL; range, 76.2–865.2 pg/mL) than in the control group (median VEGF-C: 31 pg/mL; range, 12–97 pg/mL). A significant correlation between VEGF-C levels, T, N and tumor stage has been described. The median overall survival (OS) was statistically significantly higher in pts with low serum VEGF-C levels [median: not reached (NR) vs. 26 months; P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/26210}
}