@article{JGO26936,
author = {Osama Abu-Shawer and Mohammad Abu-Shawer and Ayman Haimour and Abdullah Alhouri and Ala’a Aldeen Alkhatib and Musaab Abki and Omar Alqaisi and Omar Hamdan and Rahaf Alsaqri and Saeed Ismail and Tamer Altamimi and Maysa Al-Hussaini},
title = {Hematologic markers of distant metastases in gastric cancer},
journal = {Journal of Gastrointestinal Oncology},
volume = {10},
number = {3},
year = {2019},
keywords = {},
abstract = {Background: High neutrophil-lymphocyte ratio (NLR) is associated with poor overall survival (OS) in gastric cancer. This study evaluates whether NLR, in addition to other parameters including absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophil count (AEC), absolute monocyte count (AMC), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) are associated with distant metastases, a common and poor prognostic feature of gastric cancer.
Methods: Clinical data from 502 gastric cancer patients treated at King Hussein Cancer Center (Amman, Jordan) have been retrospectively reviewed. We examined the association between ANC, ALC, AEC, AMC, NLR, MLR and PLR with the baseline distant metastases and OS. Receiver operating characteristic (ROC) curve analysis was utilized to determine the optimal NLR cutoff value for association with distant metastases.
Results: Univariate and multivariate analyses showed that patients with high baseline NLR (≥3.9) had more distant metastases on presentation than patients with low NLR (},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/26936}
}