%0 Journal Article
%T Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation
%A Patel, Abhilasha
%A Tripathi, Gyanendra
%A McTernan, Philip
%A Gopalakrishnan, Kishore
%A Ali, Omar
%A Spector, Emma
%A Williams, Nigel
%A Arasaradnam, Ramesh P.
%J Journal of Gastrointestinal Oncology
%D 2019
%B 2019
%9 
%! Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation
%K 
%X Background: Field cancerisation proposes that there are pre-malignant genetic mutations in the macroscopically normal mucosal tissue around colorectal cancer. This study aims to evaluate fibroblast growth factor 7 (FGF7) tissue expression in the mucosal field around colorectal cancer.  Methods: Gene and protein expression of FGF7, its receptor, FGFR2 and its downstream targets; FRS2α, Erk 1/2 and Akt was measured from mucosal samples in 34 control subjects and 17 cancer patients. Serial samples from tumour, adjacent to tumour and at the resection margin were utilised.  Results: FGF7 gene expression was significantly higher in tumour (2.3-fold), adjacent mucosa (3.2-fold) and resection margin (2.8-fold) of cancer patients compared with control subjects (P
%U https://jgo.amegroups.org/article/view/27514
%V 10
%N 3
%P 429-436
%@ 2219-679X