@article{JGO28792,
author = {Katsuya Makihara and Rino Fukui and Hitomi Uchiyama and Yasushi Shigeoka and Akihiro Toyokawa},
title = {Decreased percentage of neutrophil is a predict factor for the efficacy of trifluridine and tipiracil hydrochloride for pretreated metastatic colorectal cancer},
journal = {Journal of Gastrointestinal Oncology},
volume = {10},
number = {5},
year = {2019},
keywords = {},
abstract = {Background: The concentration of trifluridine in tumor DNA was strongly correlated with that of white blood cells in tumor-bearing nude mice administered trifluridine-tipiracil (TAS-102). Further, a phase I study of TAS-102 in patients with advanced solid tumors showed a significant correlation between decreased neutrophil count and the area under the concentration-time curve of trifluridine. Herein, we aimed to evaluate the association of decreased neutrophil count with the efficacy of TAS-102.
Methods: We retrospectively analyzed 40 patients with pretreated metastatic colorectal cancer who received TAS-102 at Yodogawa Christian Hospital between June 2014 and May 2018. To evaluate the association between the efficacy of TAS-102 and decreased neutrophil count, patients were grouped into 4 categories according to the decrease of neutrophil count during the first cycle of TAS-102 as follows: Category A, },
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/28792}
}