@article{JGO3314,
author = {Jim Zhong and Manisha Palta and Christopher G. Willett and Shannon J. McCall and Frances McSherry and Douglas S. Tyler and Hope E. Uronis and Brian G. Czito},
title = {Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience},
journal = {Journal of Gastrointestinal Oncology},
volume = {5},
number = {6},
year = {2014},
keywords = {},
abstract = {Background: Ampullary adenocarcinoma is a rare malignancy associated with a relatively favorable prognosis. Given high survival rates in stage I patients reported in small series with surgery alone, adjuvant chemoradiotherapy (CRT) has traditionally been recommended only for patients with high risk disease. Recent population-based data have demonstrated inferior outcomes to previous series. We examined diseaserelated outcomes for stage I tumors treated with pancreaticoduodenectomy, with and without CRT.
Methods: All patients with stage I ampullary adenocarcinoma treated from 1976 to 2011 at Duke University were reviewed. Disease-related endpoints including local control (LC), metastasis-free survival (MFS), disease-free survival (DFS) and overall survival (OS) were analyzed using the Kaplan-Meier method.
Results: Forty-four patients were included in this study. Thirty-one patients underwent surgery alone, while 13 also received adjuvant CRT. Five-year LC, MFS, DFS and OS for patients treated with surgery only and surgery with CRT were 56% and 83% (P=0.13), 67% and 83% (P=0.31), 56% and 83% (P=0.13), and 53% and 68% (P=0.09), respectively.
Conclusions: The prognosis for patients diagnosed with stage I ampullary adenocarcinoma may not be as favorable as previously described. Our data suggests a possible benefit of adjuvant CRT delivery.},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/3314}
}