TY  - JOUR
AU  - Ness, Michael Van
AU  - Gregg, Jeffrey
AU  - Wang, Jun
AU  - Chen, Mingyi
PY  - 2012
TI  - Genetics and molecular pathology of gastric malignancy: Development of targeted therapies in the era of personalized medicine
JF  - Journal of Gastrointestinal Oncology; Vol 3, No 3 (September 01, 2012): Journal of Gastrointestinal Oncology (Current Topics in Gastrointestinal and Liver Pathology)
Y2  - 2012
KW  - 
N2  - Gastric malignancy constitutes a major cause of cancer deaths worldwide. Despite recent advances in surgical techniques combined with neoadjuvant chemotherapy and radiotherapy approaches, patients with advanced disease still have poor outcomes. An emerging understanding of the molecular pathways that characterize cell growth, cell cycle, apoptosis, angiogenesis, invasion and metastasis has provided novel targets in gastric cancer therapy. In this review, recent advances in the understanding of molecular tumorigenesis for common gastric malignancies are discussed. We also briefly review the current targeted therapies in the treatment of gastric malignancies. Practical insights are highlighted including HER2 testing and target therapy in gastric adenocarcinoma, morphologic features and molecular signatures of imatinib-resistance GISTs, and recent investigations aimed at tumor-specific therapy for neuroendocrine tumors.
UR  - https://jgo.amegroups.org/article/view/436