@article{JGO4399,
author = {Thuy B. Tran and Nicholas N. Nissen},
title = {Surgery for gallbladder cancer in the US: a need for greater lymph node clearance},
journal = {Journal of Gastrointestinal Oncology},
volume = {6},
number = {5},
year = {2015},
keywords = {},
abstract = {Background: Gallbladder cancer (GBC) is a rare malignancy with a dismal prognosis. Often identified incidentally after laparoscopic cholecystectomy for presumably benign biliary disease, reoperation with partial hepatic resection and periportal lymph node dissection (LND) is frequently performed. The impact of lymph node (LN) clearance for GBC remains unclear.
Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for patients diagnosed with GBC between 1988 and 2009. Survival was calculated using Kaplan-Meier method and compared using log-rank test. Multivariate analysis was performed to identify predictors of survival.
Results: A total of 11,815 patients diagnosed with GBC were identified. Cancer-directed surgery was performed in 8,436 (71.3%) patients. Optimal LN clearance (defined as ≥4 LNs) is associated with young age, advanced T-stage, no radiation therapy, and radical surgery (all },
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/4399}
}