@article{JGO5802,
author = {Daniel G. Tanenbaum and William A. Hall and Lauren E. Colbert and Amanda J. Bastien and Daniel J. Brat and Jun Kong and Sungjin Kim and Bhakti Dwivedi and Jeanne Kowalski and Jerome C. Landry and David S. Yu},
title = {TNFRSF10C copy number variation is associated with metastatic colorectal cancer},
journal = {Journal of Gastrointestinal Oncology},
volume = {7},
number = {3},
year = {2015},
keywords = {},
abstract = {Background: Genetic markers for distant metastatic disease in patients with colorectal cancer (CRC) are not well defined. Identification of genetic alterations associated with metastatic CRC could help to guide systemic and local treatment strategies. We evaluated the association of tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) copy number variation (CNV) with distant metastatic disease in patients with CRC using The Cancer Genome Atlas (TCGA).
Methods: Genetic sequencing data and clinical characteristics were obtained from TCGA for all available patients with CRC. There were 515 CRC patient samples with CNV and clinical outcome data, including a subset of 144 rectal adenocarcinoma patient samples. Using the TCGA CRC dataset, CNV of TNFRSF10C was evaluated for association with distant metastatic disease (M1 vs. M0). Multivariate logistic regression analysis with odds ratio (OR) using a 95% confidence interval (CI) was performed adjusting for age, T stage, N stage, adjuvant chemotherapy, gender, microsatellite instability (MSI), location, and surgical margin status.
Results: TNFRSF10C CNV in patients with CRC was associated with distant metastatic disease [OR 4.81 (95% CI, 2.13–10.85) P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/5802}
}