@article{JGO871,
author = {Ju-Li Koh and Winston Liauw and Terence Chua and David L. Morris},
title = {Carbohydrate antigen 19-9 (CA 19-9) is an independent prognostic indicator in pseudomyxoma peritonei post cytoreductive surgery and perioperative intraperitoneal chemotherapy},
journal = {Journal of Gastrointestinal Oncology},
volume = {4},
number = {2},
year = {2013},
keywords = {},
abstract = {Introduction: Pseudomyxoma peritonei (PMP) is characteristically divided into two histopathological subtypes; disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis (PMCA). The latter is associated with a worse prognosis. However, even within the DPAM group, there is a considerable variation in outcome. In this study we investigate the role of baseline serum tumor markers CA-19.9, CEA and CA-125 in further stratifying survival.
Methods: Over 16 years, 218 patients with PMP were treated with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) at our institution. A CA-125 level of >35 U/L, CA-19.9 of >40 U/mL and CEA of >3 ng/mL were considered positive or elevated outside the laboratory reference range. The impact of clinicopathologic and treatment-related variables on overall survival (OS) was analyzed with the Kaplan Meier method. Survival curves were compared using the log-rank test. Variables deemed significant by univariate analyses were entered into multivariate analysis using the Cox proportional hazards model.
Results: Within the DPAM group, the 5-year survival of patients who were CA-19.9 positive versus those with normal values were 58% and 90% respectively (P},
issn = {2219-679X}, url = {https://jgo.amegroups.org/article/view/871}
}