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Original Article

Definitive chemoradiotherapy versus radiotherapy alone for locally advanced esophageal cancer in elderly patients aged ≥75 years: a population-based retrospective cohort study

Lu Luo, Chunmei Gong, Chunyan Deng

Published online: 30 October 2026

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Original Article

Development and internal validation of a nomogram for predicting early rebleeding after endoscopic variceal ligation in patients with cirrhosis, including those with hepatocellular carcinoma

Pei-Hong Zhang, Chen-Sen Huang, Ou Qian

Published online: 30 October 2026

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Original Article

Construction of a prediction model for early recurrence after endoscopic ultrasound-guided injection ablation in insulinoma patients

Zeping Deng, Shanyu Qin, Haixing Jiang

Published online: 28 October 2026

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Original Article

Characterization of patient-derived colorectal cancer organoids and exploratory RAS-directed drug-response testing

Ruobing Chen, Chun Wang, Wanrong Lin, Lei Liang, Li Yan, Xin Li, Ni An, Jun Yang, Weiqing Liu

Published online: 28 October 2026

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Review Article

MALAT1 and therapeutic resistance in hepatocellular carcinoma: drug-specific mechanisms, ferroptosis-related evidence, and contextual viral and microenvironmental biology—a narrative review

Shuang Liu, Fu-Yu Hua, Chen Chen

Published online: 28 October 2026

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Original Article

A retrospective study of treatment outcomes and toxicity of chemoradiation in human immunodeficiency virus-positive and negative patients with anal squamous cell carcinoma in the modern era

Kara M. Banson, Gabriel Fuligni, Cheongeun Oh, Benjamin T. Cooper, Jason Domogauer, Colin Hill, Anand Mahadevan, Kevin L. Du, Fauzia Shaikh

Published online: 28 October 2026

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Original Article

Comparison of MultiVane and modified Dixon magnetic resonance imaging sequences: image quality assessment and diagnostic performance for pathologic complete response evaluation in locally advanced rectal cancer after neoadjuvant therapy

Si Xu, Liu Hu, Lan Zhang, Quan Chen, Ning Zheng, Ziqiao Lei, Yuan Liu

Published online: 28 October 2026

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Original Article

Molecular architecture and epigenetic acceleration in early-onset gastric cancer: insights from a Chilean cohort

Cristopher San Martin Abello, María E. Avendaño, Fernando Sigler Chávez, Javiera Veas-Torres, Daniela I. Miranda, Felipe Salinas Barriga, Marcelo Garrido Villanueva, Andrea C. Sabioncello, Mauricio A. Sáez, Marialvis Nava Brito, Tania Manriquez Flores, Henry Barrios, Pelegrino Romano de la Torre, Wladimir Flores, Nicolas Cueto, Fernan Gomez-Valenzuela, René Letelier Farías, Juan A. Godoy, Marcelo Garrido

Published online: 28 October 2026

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Original Article

Computational profiling links a spatially organized THBS1-associated macrophage niche to reduced KLRD1⁺ CD8⁺ T-cell infiltration and poor outcome in hepatocellular carcinoma

Bowen Wu, Rongsen Wang, Xiao Tang, Libin Dong, Chenghao Cao, Huigang Li, Wei Shen, Yuanming Chen, Yuhang Li, Zijian Lou, Ye Tao, Shengjun Xu, Xinyu Yang, Xiao Xu, Di Lu

Published online: 28 October 2026

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Original Article

HAWT-nnU-Net: development and evaluation of a hybrid attention and wavelet decomposition deep learning model for rectal cancer clinical target volume segmentation

Guangbiao Pan, Xiaoqin Huang, Yiheng Hu, Yiren Wang, Yiqi Lai, Yiran Wu, Yuhan He, Yunfei Li, Yan Peng

Published online: 28 October 2026

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Original Article

Where you come from affects when you get treated: The Implications of Country-of-Origin on Time-to-Treatment in Hispanic Colon Cancer Patients

Natalia Perez Baez, Narjes Sweis, Hitesh Kapoor, Lily Zhang, Elisa Bianchi, Mohamad A. Abdulhai, Alejandra Perez-Tamayo, Gerald Gantt

Published online: 26 October 2026

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Original Article

Impact of postoperative chemotherapy on the prognosis of older adult patients with stage IV gallbladder adenocarcinoma: an analysis of the Surveillance, Epidemiology, and End Results database

Chuan Jiang, Bo Cai, Linhui Gong, Chen Gong, Shiqing Gong

Published online: 26 October 2026

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Original Article

Development and internal validation of a clinicogenetic nomogram incorporating the germline host variant rs3997872 near HLA-DRB1 for overall survival after curative-intent resection of hepatocellular carcinoma: a single-center retrospective cohort study

Delong MM, Zhenglong MM, Yuanyuan MM, Guocheng BM, Xiaofang MD

Published online: 26 October 2026

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Original Article

Survival outcomes of metastatic Colorectal Cancer (mCRC) patients receiving first-line chemotherapy: A single Institution experience

Fiorenza Santamaria, Francesco Nicolella, Lucia Sacco, Anna Calora, Iolanda Speranza, Daniele Santini, Vincenzo Bianco

Published online: 26 October 2026

Open Access

Original Article

Assessment of quality of life after subtotal and total gastrectomies for gastric cancer

Raquel Lacerda Dantas de Farias, Wilson Luiz da Costa Júnior, Igor Correia de Farias, Silvio Melo Torres, Alessandro Landskron Diniz, Heber Salvador de Castro Ribeiro, André Luis Godoy, Dante Altenfelder Silva Mesquita Cortelli, Felipe José Fernández PhD

Published online: 26 October 2026

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Review Article

Artificial Intelligence in MASLD-HCC: Risk Prediction, Early Detection, Mechanistic Insights, and Target Discovery: a narrative review

Shangqi Hu, Li Ying, Shuanglin Han

Published online: 26 October 2026

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Original Article

Nothing but NET: A Retrospective Cohort Study of Gastroenteropancreatic Neuroendocrine Tumors Diagnosed in a Hispanic Rich South Texas Population

Leen S. Azeez, Keerthi Thallapureddy, Chioma Owo, Adam Vinall, Grecia Dominguez Rivera, Daniel Nyancho, Pradeep Yarra, Sukeshi Arora, Laura Rosenkranz

Published online: 26 October 2026

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Original Article

Perioperative Immune Checkpoint Inhibitor Plus Chemotherapy Versus Chemotherapy Alone for Locally Advanced Gastric Cancer and Gastroesophageal Junction Adenocarcinoma: A Systematic Review and Meta-Analysis

Yurong Wang, Xiao Huang, Xinran Gao, Bangwei Cao, Bing Liu

Published online: 26 October 2026

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Original Article

Diagnostic performance of quantitative dynamic contrast-enhanced magnetic resonance imaging for post-neoadjuvant assessment of mesorectal lymph nodes ≥5 mm in rectal cancer

Zhiwen Zhang, Yan Chen, Xuehan Wu, Shaoqing Niu, Ziqiang Wen, Wenjie Fan, Quanmeng Liu, Yiyan Liu, Yunzhu Wu, Yutao Que, Shenping Yu, Yuru Ma

Published online: 26 October 2026

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Original Article

Preoperative Serum PLXNA3 for Overall Survival Prediction in Stage I-III Colorectal Cancer: Machine-Learning Biomarker Discovery and Development with Internal Validation of a Prognostic Model

Wenchao Xiu, Wei Zheng, Ting Zhang, Zhen Xu

Published online: 26 October 2026

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Brief Report

Average relative dose intensity-based dose optimization in outpatient chemotherapy for stage IV colorectal cancer: a single-center retrospective study from Japan

Takayuki Tajima, Masaya Mukai, Shigeo Higami, Daiki Yokoyama, Sayuri Hasegawa, Shigeya Takeo, Lin Fung Chan, Hideki Izumi, Kazutake Okada, Hiroyasu Makuuchi

Published online: 26 October 2026

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