Vol 16, No 4 (August 30, 2025): Journal of Gastrointestinal Oncology

Original Article

Sarcopenia following concurrent chemoradiotherapy for locally advanced esophageal squamous cell carcinoma
Thiranai Vongcharoenpol, Wongsakorn Chaochankit, Sakchai Ruangsin, Supparerk Laohawiriyakamol, Siriporn Leelakiatpaiboon, Natee Ina, Rungarun Kittichet, Patrapim Sunpaweravong, Somkiat Sunpaweravong
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1358-1365
.
 (30 August 2025) 
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Effects of anlotinib combined with camrelizumab and chemotherapy as first-line treatment for advanced esophageal squamous cell carcinoma on tumor immune microenvironment
Mingfang Xu, Yingda Liu, Xunjie Kuang, Xiuyong Liao, Xiaodong Zhao
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1366-1379
.
 (30 August 2025) 
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Poorer prognosis of early gastric cardia cancer compared to early gastric non-cardia cancer: evidence from SEER database analysis
Shuang Ma, Liuqing Yao, Bo Yang, Zhuo Huang, Chenfei Shao, Lanping Zhu, Xin Chen
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1380-1392
.
 (30 August 2025) 
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Tumor necrosis, an independent prognostic factor for predicting gastric gastrointestinal stromal tumors
Kunlong Chang, Renjie Li, Peng Zhang, Tao Chen, Haibo Qiu, Yongjian Zhou, Chunyan Du, Xiaonan Yin, Fang Pan, Guoliang Zheng, Yan Zhao, Xiufeng Liu, Jian Li, Bo Zhang, Ye Zhou, Jiang Yu, Kaixiong Tao, Yong Li, Xingyu Feng
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1393-1402
.
 (30 August 2025) 
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Global burden of gastric cancer attributed to high-salt diets: spatiotemporal trends and socio-demographic inequalities from 1990 to 2021
Wei Liu, Yang Liu, Hua-Wan Chen, Zhen-Zhen Peng, Kui Liao
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1403-1419
.
 (30 August 2025) 
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Retrospective analysis of Claudin18.2 expression in ethnically diverse patients with gastroesophageal adenocarcinoma
Sara Wallam, Jimyung Park, Lawrence W. Wu, Ryan H. Moy
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1420-1433
.
 (30 August 2025) 
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Value of the systemic immune inflammation index in predicting the efficacy of neoadjuvant chemotherapy in patients with gastric cancer: a multicenter retrospective clinical study
Li Yang, Min Chen, Wei Wang, Minghui Meng, Fengying Wu, Jiani Lv, Arvind Sahu, Yuanyuan Jiao
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1434-1442
.
 (30 August 2025) 
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NKAP overexpression promotes gastric cancer immune escape by inducing IL-10 secretion from mature dendritic cells during anti-PD-L1 therapy
Bingna Yan, Pei Zhang, Qianhe Zu, Shan Liu, Pan Wang, Yaning Wei, Jialin Liu, Shun Zhang, Yanan Wang, Zhe Han
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1443-1460
.
 (30 August 2025) 
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The clinical value of spectral computed tomography reconstruction technology for the anatomy of the superior mesenteric artery in laparoscopic radical right hemicolectomy for colon cancer: a cross-sectional study
Jinghao Chen, Hao Tian, Ke Yu, Shumin Tao, Bin Bai, Anyi Song, Hongmei Gu
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1461-1473
.
 (30 August 2025) 
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Diagnostic value of endoscopic ultrasound versus indocyanine green fluorescence imaging for sentinel and lymph node metastasis in patients with colorectal cancer
Guocong Wu, Yu Huang, Meifeng He, Chenggang Ren, Zhuo Wang, Yangyang Liu, Yao Zhang, Jianyong He, Shaoshuai Liu, Zhengeng Jia
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1474-1482
.
 (30 August 2025) 
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Prognostic nomogram for overall survival in rectal cancer with synchronous lung metastases using Surveillance, Epidemiology, and End Results data and a single-center external validation cohort
Liyu Cao, Liting Lyu, Bin Wang, Xiaofang Dong
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1483-1497
.
 (30 August 2025) 
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Proximal vs. distal colon cancer location: a subset analysis of the Minnesota colon cancer control study
Alexander Troester, Claire Sokas, Jack M. Wolf, Kyle Rudser, Timothy R. Church, Aasma Shaukat, Paolo Goffredo
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1498-1502
.
 (30 August 2025) 
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Identification of prognostic biomarkers in colorectal cancer through multi-omics profiling of programmed cell death pathways
Song Qiao, Shangzhen Yang, Hua Hua, Chengtao Mao, Xiaolong Li, Cai Cheng, Hongguo Guo, Wanling Lu
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1503-1520
.
 (30 August 2025) 
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Colorectal cancer prognosis: insights from the tumor immune microenvironment and gut microbiota
Quan Chen, Youtao Zhou, Zikai Lin, Cuiyan Yang, Hui Chen, Chuanfeng Ke
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1521-1533
.
 (30 August 2025) 
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Fear of cancer recurrence and associated factors in Chinese patients with colorectal cancer: a cross-sectional study
Lijuan Xu, Wenli Dai, Li Chen, Lifeng Yao
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1534-1549
.
 (30 August 2025) 
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Andrographolide potentiates anti-tumor immunity in colorectal cancer (CRC) by targeting voltage-dependent anion channel (VDAC) and activating the cGAS-STING axis
Jiaming Wu, Ben Li, Yutong Chen, Mili Zhang, Jin Li, Guangjian Dou, Yuping Peng, Liyong Huang, Yan Zhou, Zhiheng Chen
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1550-1561
.
 (30 August 2025) 
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Establishment of a prognostic nomogram for intrahepatic cholangiocarcinoma patients receiving chemotherapy: a SEER-based study
Qiuhan Heng, Mingxing Hou, Ying Leng, Hua Yu
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1562-1572
.
 (30 August 2025) 
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Tumor-informed circulating tumor DNA assay for surveillance post-liver transplantation in patients with hepatocellular and cholangiocarcinoma
Maen Abdelrahim, Ashton A. Connor, Abdullah Esmail, Ahmed Elaileh, Souha Farhat, Sudha Kodali, David W. Victor III, Elizabeth W. Brombosz, Ashish Saharia, Linda W. Moore, R. Mark Ghobrial
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1573-1585
.
 (30 August 2025) 
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Survival of hepatectomy in colorectal cancer patients with ten or more liver metastases: a retrospective cohort study of multidisciplinary treatment
Ping Lu, Yaqi Li, Zhiyu Chen, Jianling Zou, Junjie Peng
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1586-1596
.
 (30 August 2025) 
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Real-world second-line treatment pattern for unresectable or advanced hepatic carcinoma in China: a retrospective database study
Jiahua Leng, Jing Wu, Rong Han, Huan Wei, Ken Chen
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1597-1609
.
 (30 August 2025) 
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Efficacy of stereotactic body radiotherapy in hepatocellular carcinoma with adrenal metastases: a retrospective analysis
Xi Cheng, Jing Li, Yong Li, Fenghua Liu, Tiehua Li, Yan Meng, Miaomiao Wang
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1610-1621
.
 (30 August 2025) 
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DDX18 promotes growth and metastasis of hepatocellular carcinoma via activating EMT and MAPK signaling
Xiaodong Xu, Xiaoxia Yu, Nannan Zhang, Feiran Wang, Zhong Chen
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1622-1634
.
 (30 August 2025) 
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GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma
Xuehong Wang, Lanyu Li, Tian Sun, Zhidong Qiu
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1635-1647
.
 (30 August 2025) 
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Clinical significance of transjugular intrahepatic portosystemic shunting for hepatocellular carcinoma complicated with portal hypertension
Feng Dai, Chunhan Pan, Chunyang Xu, Yu Yao, Mu Su, Jianwu Ren, Zhiyuan Qiu, Mario Capasso, Xiuming Zhang
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1648-1657
.
 (30 August 2025) 
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Stereotactic body radiation therapy in oligometastatic pancreatic cancer: overall survival improvement and SMAD4 as a predictor of progression-free survival
Ahmed Elhariri, Jaydeepbhai Patel, Himil Mahadevia, Karnav Modi, Douaa Albelal, Umair Majeed, Jeremy C. Jones, Mitesh J. Borad, Nguyen H. Tran, Michael S. Rutenberg, Hani Babiker
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1658-1666
.
 (30 August 2025) 
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The incidence and risk factors of venous thromboembolism in patients with pancreatic cancer: a systematic review and meta-analysis
Xinyao Zhou, Yunlan Jiang, Heyao Xu, Xiaodi Bai, Siyu Lin, Ting Xu, Shulan Liu
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1667-1681
.
 (30 August 2025) 
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Local radiotherapy polarized tumor-associated macrophages enhance the efficacy of Claudin18.2-targeted CAR-T therapy in pancreatic cancer
Xiaokang Zhang, Hongtai Shi, Leran Qiu, Zhunyi Gao, Jiahe Xu, Xingyu Zhou, Zeya Xia, Ganesh Radhakrishna, Jiao Xue, Songbing Qin
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1682-1698
.
 (30 August 2025) 
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Mechanistic insights into the anti-tumor effects of neochlorogenic acid in hepatocellular carcinoma: in vitro and in vivo studies
Menglong Xu, Yongchao Li, Wenqiang Sun, Haocheng Guan, Ruijun Shi, Shuwei Li
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1699-1710
.
 (30 August 2025) 
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A novel lactylation-related signature for predicting esophageal cancer prognosis and immune infiltration
Liming Xie, Qiuxing Yang, Wenjing Zhao, Guangzhi Lan, Guomei Tai
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1711-1735
.
 (30 August 2025) 
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Case Series

The combination of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), interventional hepatoma therapy, targeted therapy, and immunotherapy: a case series of a novel AITI conversion therapy model
Zhu Chen, Xingyu Chen, Haiyang Hu, Kai Chen, Heng Xiao, Chengyou Du, Xiang Lan
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1736-1748
.
 (30 August 2025) 
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Case Report

A germline variant of ring finger protein 43 in an early onset, treatment-resistant metastatic gastric cancer: a case report
Benjamín García-Bloj, Santiago Farah Celis, Natalia Eva Orellana, Tomás de Mayo Glasser, Mauricio A. Sáez, Ignacio N. Retamal, Matías Muñoz-Medel, Carolina Sánchez, Felipe Pinto, Paola Aravena, Cristopher San Martín, Andrea C. Sabioncello H., Marcelo Garrido Villanueva, Fernando Sigler Chávez, Juvenal A. Ríos Leal, Patricio A. Manque, José M. Erpel, Juan A. Godoy, Marcelo Garrido
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1749-1755
.
 (30 August 2025) 
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Case report of carcinoid syndrome with multi-organ involvement
Matthew Everett, Saurin Chokshi
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1756-1762
.
 (30 August 2025) 
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Editorial Commentary

Rethinking surrogate endpoints in metastatic colorectal cancer: counting chickens only when they hatch
Luis I. Ruffolo, Michael D’Angelica
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1763-1767
.
 (30 August 2025) 
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The surgical perspective on CAIRO5 and beyond: all patients with colorectal liver metastases should be evaluated by a liver surgeon, but what defines resectability?
Victoria S. Wu, Lee M. Ocuin
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1768-1772
.
 (30 August 2025) 
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Editorial

New dosing schedules in pre-treated patients with metastatic colorectal cancer
Per Pfeiffer, Line Schmidt Tarpgaard
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1773-1778
.
 (30 August 2025) 
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Progress in precision therapies for advanced cholangiocarcinoma: inhibitors of FGFR1–3
Jonathan Wadsley
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1779-1781
.
 (30 August 2025) 
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Impact of new onset diabetes on pancreatic cancer outcomes
Casey P. Borowsky, Peter J. Hosein
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1782-1784
.
 (30 August 2025) 
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Efficacy of liquid biopsy in colorectal cancer
Masahiro Yan, Nozomi Funatsu, Megumu Watanabe, Hiroyuki Uetake
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1785-1788
.
 (30 August 2025) 
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Erratum

Erratum: Activation of RhoA/ROCK2 signaling by hypoxia-inducible factor 1α in promoting tumor growth and metastasis in human colon cancer
Editorial Office
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1789-1790
.
 (30 August 2025) 
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Erratum: Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK
Editorial Office
Journal of Gastrointestinal Oncology  
2025;
16
(4)
:1791-1795
.
 (30 August 2025) 
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