Meta-analysis and systematic review of the relationship between ulcerative colitis and colon cancer
Letter to the Editor

Meta-analysis and systematic review of the relationship between ulcerative colitis and colon cancer

Li Zhang1,2, Huatian Gan1,3

1Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China; 2Department of Geriatrics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China; 3Lab of Inflammatory Bowel Disease, Clinical institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China

Correspondence to: Huatian Gan. The Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, China. Email: ganhuatian@126.com.

Response to: Guo Q, Xu Q, Zhu X, et al. Was ulcerative colitis one of the risk factors of colorectal cancer? J Gastrointest Oncol 2022;13:3340.

Submitted Mar 17, 2022. Accepted for publication Oct 21, 2022.

doi: 10.21037/jgo-22-264

We thank Guo et al. for their comments on our published article “Secondary colon cancer in patients with ulcerative colitis: a systematic review and meta-analysis” (1).

After verification, the interpretation of P<0.00001 is significantly different, so it is concluded that there is a relationship between colon cancer and colitis (2). After consideration, in prospective studies, such as cohort studies and randomized controlled trial (RCT), not only relative risk (RR) but also odds ratio (OR) can be calculated (3). Generally, RR is used in many cohort studies and RCT when reporting the results. However, the overall rate of this study is low, so OR is similar to RR, and so it is correct to use OR.

Acknowledgments

Funding: The present work was supported by the National Natural Science Foundation of China (No. 81470826), the Science Foundation from Science & Technology Department of Sichuan Province (No. 2019YFS0262; No. 2020YFS0410; No. 22ZDYF1691; No. 2018FZ0062) and 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No. ZYGD18023).

Footnote

Provenance and Peer Review: This article was a standard submission to the journal. The article did not undergo external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-22-264/coif). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

References

  1. Guo Q, Xu Q, Zhu X, et al. Was ulcerative colitis one of the risk factors of colorectal cancer? J Gastrointest Oncol 2022;13:3340.
  2. Shivakumar BM, Lakshmankumar B, Rao L, et al. Colorectal neoplasia in long-standing ulcerative colitis - a prospective study from a low-prevalence area. Colorectal Dis 2013;15:e462-8. [Crossref] [PubMed]
  3. Hilmi I, Singh R, Ganesananthan S, et al. Demography and clinical course of ulcerative colitis in a multiracial Asian population: a nationwide study from Malaysia. J Dig Dis 2009;10:15-20. [Crossref] [PubMed]
Cite this article as: Zhang L, Gan H. Meta-analysis and systematic review of the relationship between ulcerative colitis and colon cancer. J Gastrointest Oncol 2022;13(6):3338-3339. doi: 10.21037/jgo-22-264

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