Vol 17, No 4 (August 31, 2026): Journal of Gastrointestinal Oncology

Original Article

Prognostic significance of DNA damage response-related markers in esophageal squamous cell carcinoma using machine learning approaches
Chao Huang, Yan-Jiao Zhang, Fan Zhang, Chun-Yue Gai, Zhen-Hua Li, Hui-Lai Lv, Shi-Wang Wen, Zi-Qiang Tian
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:204
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 (31 August 2026) 
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The association between coffee consumption and esophageal cancer risk: a systematic review and meta-analysis of current observational evidence
Yiwei Zhao, Zixin Cai, Jingjing Zhang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:205
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 (31 August 2026) 
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FANCI promotes esophageal squamous cell carcinoma progression and cell cycle regulation and interacts with FANCD2
Beibei Hua, Tao Ye, Huijie Huang, Weiwei Wang, Xuezhi Chang, Ruozheng Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:206
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 (31 August 2026) 
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Human epidermal growth factor receptor 2 expression loss after neoadjuvant chemotherapy in localized gastroesophageal adenocarcinoma: a retrospective study
Jean-Baptiste Demigné, Marie Heinisch, Julia Gilhodes, Shems Kettani, Domitille Dano, Christelle de la Fouchardière
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:207
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 (31 August 2026) 
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Efficacy and safety of sintilimab-based neoadjuvant regimens in patients with resectable gastric or gastroesophageal junction adenocarcinoma: a single-arm systematic review and meta-analysis
Tingting Nan, Siheng Lian, Xiaohong Wu, Ruina Cai, Yumei Cai, Yonglong Su, Xiaoyun Ye, Yuhong Huang, Jinbao Wei, Ruping Ni
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:208
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 (31 August 2026) 
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Prediction-model development and temporal validation for six-month cancer-specific mortality in de novo metastatic gastroesophageal junction adenocarcinoma: a SEER-based study
Lunjian Xia, Ziao Wang, Xiaoqian Guo, Xueting Men, Weikun Fan, Qifeng Lu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:209
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 (31 August 2026) 
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Early hypoalbuminemia during zolbetuximab therapy in gastroesophageal adenocarcinoma: a retrospective observational study
Fares Jamal, Cody Eslinger, Abdullah Alsulaiman, Tanios Bekaii-Saab, Hao Xie, Daniel Ahn, Jason S. Starr, Jake Jochum, Nguyen H. Tran, Mojun Zhu, Ben George, Caitlin B. Conboy, Conor D. J. O’Donnell, Jamie Bering, Harry H. Yoon, Mohamad Bassam Sonbol
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:210
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 (31 August 2026) 
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Nodal status and advanced clinical stage as determinants of response and survival after induction chemoradiotherapy in esophageal and gastroesophageal junction cancer: a single-centre retrospective cohort study
Sabrina Schaefer, Sindhu Kanjeekal, Tarek Elfiki, John Mathews, Akmal Ghafoor, Abdullah Nasser
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:211
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 (31 August 2026) 
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Screening of molecular biomarkers ASPN and LBH and construction of a prediction nomogram for the progression of esophagogastric junction adenocarcinoma
Ye Chen, Liuhong Yuan, Huihui Sun, Ying Chen, Bo Li, Meng Qian, Zhenxiang Wang, Yan Zhang, Jie Xiong, Qian Liang, Kun Tao, Zhenyu Tan, Shuchang Xu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:212
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 (31 August 2026) 
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Non-structural maintenance of chromosome condensin I complex subunit H knockdown suppresses malignant progression of esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway
Yang Xu, Ao Guo, Jing Yang, Mingjun Zhang, Bin Yuan
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:213
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 (31 August 2026) 
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The prognosis of patients with gastrointestinal stromal tumors harboring the KIT exon 11 mutation: a retrospective cohort study
Chunhui Shou, Weili Yang, Xiaodong Wang, Qi Zhang, Jiren Yu, Tingbo Liang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:214
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 (31 August 2026) 
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Cuproplasia-associated LOXL2 cooperates with Helicobacter pylori infection to promote gastric cancer progression via the FAK/Src signaling axis
Jin Wang, Wenzi Meng, Jiahui Zhu, Guangzhao Tao, Yujian Xia, Yao Li, Xin Zhao, Yunliang Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:215
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 (31 August 2026) 
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Development and validation of a nomogram for the non-invasive prediction of human epidermal growth factor receptor 2 expression in gastric adenocarcinoma: an 18F-fluorodeoxyglucose positron emission tomography/computed tomography-based study
Sijie Yang, Xiuqing Xue, Wen Jiang, Minyi Wang, Xinyi Zhang, Yu Chen, Dachuan Zhang, Qi Zhou, Yuetao Wang, Xiaoliang Shao
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:216
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 (31 August 2026) 
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Non-invasive prediction of occult peritoneal metastasis (OPM) in gastric cancer using logistic regression and random forest integrative models with CT radiomics and clinical parameters: machine learning prediction of gastric OPM
Yuzhe Han, Shuai Xiang, Hanhui Jing, Hongyu Cao, Ying Li, Jiazhen Sui, Jinlong Deng, Ning Ding, Shanglong Liu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:217
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 (31 August 2026) 
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Helicobacter pylori-induced cystathionine-γ-lyase drives redox imbalance and metabolic remodeling in gastric cancer
Yangyang Wang, Ruixue Xu, Ziqi Wang, Yufei Wu, Shuyi Han, Xi Zhang, Huanjie Li
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:218
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 (31 August 2026) 
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Development of a postoperative risk scoring tool for elderly patients with early gastric cancer: an exploratory prognostic score derivation study
Juno Yoo, Byungmoon Chung, Junghwan Kim, Seong-A Jeong, Sa-Hong Min, Chung Sik Gong, In-Seob Lee, Beom Su Kim, Moon-Won Yoo, Jeong Hwan Yook, Sehee Kim, Chang Seok Ko
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:219
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 (31 August 2026) 
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Increased expression of Ribonucleic acid export 1 (RAE1) gene promotes gastric carcinogenesis and is associated with activation of Hippo signaling pathway
Qianyu Zhu, Yanling Li, Qin Ouyang, Pingping He, Sisi Chen, Donghu Zhou, Yanmeng Li, Jie Xing, Huaduan Zi, Hengcheng Tang, Shuilong Guo, Jian Huang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:220
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 (31 August 2026) 
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Impact of spatial distribution of M2 macrophages on prognosis and neoadjuvant chemotherapy resistance in gastric cancer
Yangquan Li, Can Luo, Dongfang Li
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:221
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 (31 August 2026) 
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Distinct metastatic patterns and survival outcomes in intestinal- versus diffuse-type gastric cancer: a SEER-based propensity score-matched analysis
Yan Ming, Aiping Shang, Yin Zhou, Xiangmei Zhao
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:222
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 (31 August 2026) 
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Clinical efficacy and safety of apatinib plus S-1 combined with oxaliplatin (SOX) in postoperative stage III gastric cancer patients with high VEGFR-2 expression
Qin Deng, Rong Wang, Hongbin Qi, Yongjin Zhou, Jiaju Chen, Lei Zhang, Xiaoqiang Gao, Xiangren Jin, Zhiqiang Yan, Haibin Wang, Qian Wang, Hongxin Yang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:223
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 (31 August 2026) 
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A predictive nomogram model for overall survival in obstructive colorectal cancer based on clinical and laboratory indicators
Pingxia Lu, Wanyun Su, Dingman Huang, Xinyu Huang, Cuifeng Zheng, Baowei Xu, Xianqiang Chen, Junrong Zhang, Zhengyuan Huang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:224
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 (31 August 2026) 
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Trajectory identification of high-risk subgroups after colorectal cancer surgery in patients with minimal residual disease: a single-center longitudinal study
Yahan Zhang, Lei Liang, Ruize Zhou, Shirong Wu, Yicheng Zhou, Jinjin Luo, Yujian Zeng, Ning Xu, Zhengqi Wen
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:225
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 (31 August 2026) 
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Histopathological subtypes independently predict survival in ampullary carcinoma: a contemporary SEER nomogram study
Minghui Zhang, Kuinan Tong, Chao Jing, Hongwei Wu, Xuemei Du, Kun Liu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:226
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 (31 August 2026) 
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Sphingosine-1-phosphate induces angiogenesis via the activating STAT3 signaling pathway to drive colorectal cancer progression
Qianlong Ling, Qidong Chen, Ruipeng Wang, Wenjiang Man, Liang Yan, Bowen Han, Zhongxu Yuan
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:227
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 (31 August 2026) 
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Artemisinin inhibits colorectal cancer progression via the FAM83A-AS1/HIF-1α axis
Jinchuan Xi, Zhihan Li, Youqiang Liu, Zheng Li, Wenbo Niu, Lianmei Zhao, Bin Yu, Guiying Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:228
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 (31 August 2026) 
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Metabolic-cell-death gene trio predicts survival and cuproptosis sensitivity in colorectal cancer
Wei Zhuang, Ya Zhang, Zhengyong Liu, Wenxue Yan, Tao Wei, Qiuping Deng, Qi Liu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:229
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 (31 August 2026) 
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Real-world efficacy and safety of fruquintinib plus PD-1 inhibitors with or without radiotherapy in refractory metastatic colorectal cancer: a single-center retrospective cohort study
An Yi, Lihong He, Xin Liu, Zhuoyu He, Jin Liu, Bin Li, Huaiwen Zhang, Yan Liu, Chunling Jiang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:230
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 (31 August 2026) 
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Association between metabolic dysfunction-associated steatotic liver disease and risk of early-onset advanced colorectal neoplasia: a systematic review and meta-analysis
Yan Zhong, Xianhang Li, Siqi Chen, Min Deng
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:231
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 (31 August 2026) 
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MS4A3 as a potential prognostic biomarker for colon cancer: integrated analysis of expression patterns and immune cell infiltration
Li Feng, Qin Hao, Jing Fan, Guizhen Gao, Xu Gao, Hongyang Zhang, Rigetu Zhao, Yu Wu, Yang Hao, Zhenfei Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:232
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 (31 August 2026) 
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Radiomic prediction of early progression at 2 years post-treatment in patients with resectable rectal cancer based on rectal tumor and mesentery characteristics: a two-center study
Tao Quan, Lei Wu, Shuangqing Chen, Yuanqing Liu, Lu Lu, Jie Zhu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:233
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 (31 August 2026) 
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Prognostic significance of lymphovascular invasion in colorectal mucinous adenocarcinoma after curative resection: a nationwide multi-center retrospective cohort study
Tianhao Wang, Bin Ren, Haoqing He, Peng Zhang, Changqing Jing, Xu Guan, Yueming Sun, Yifei Zhang, Shanglei Ning, Minhao Yu, Yanfeng Lv, Lei Wang, Meng Jiao, Yanlai Sun, Qi Sun, Dongning Liu, Xianghai Ren, Zhibin Ye, Zhao Zhang, Jun Li, Bin Ma, Guodong Yu, Wei Fu, Guangyong Zhang, Hui Yang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:234
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 (31 August 2026) 
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A study on screening of postoperative chemotherapy beneficial populations in stage II colorectal cancer based on diffusion weighted imaging and 18F-fluorodeoxyglucose positron emission tomography/computed tomography
Xuedong Wang, Lei Li, Linjie Wang, Weipeng Chen
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:235
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 (31 August 2026) 
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Prognostic value of genes associated with metastasis and propionate metabolism in rectal cancer
Jialei Wang, Peiwei Fang, Qingying Tan, Feng Chen, Min Ni
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:236
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 (31 August 2026) 
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Global, regional, and national burden of colorectal cancer attributable to modifiable risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Miao Yu, Yi-Ping Lu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:237
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 (31 August 2026) 
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Prognostic impact of mucinous adenocarcinoma after curative surgery for stage I–III colorectal cancer: a large population-based cohort study
Jiyang Li, Tengyu Zeng, Xianqiang Xie, Dongsheng Li, Kejin Yan, Hongliang Zhu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:238
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 (31 August 2026) 
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Comparative analysis of outcomes and sociodemographic factors in early- and late-onset colorectal cancer hospitalizations
Manali Shah, Ravi Upadhyay, Lawanya Singh, Shari Forbes, Maliyat Matin, Sharon Li
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:239
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 (31 August 2026) 
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Modifiable risk factors contributing to the rising incidence of early-onset colorectal cancer in the United States over three decades: a Global Burden of Disease analysis
Mohammed Y. Youssef, Mohamed H. Eldesouki, EzzElDien A. Ibrahim, Mohamed Elgozair, Mona A. Ali, Ahmed Salem, Mohammed Bakry, Asim Usman, Aasma Shaukat, Sherif E. Elhanafi
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:240
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 (31 August 2026) 
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Establishment of a chemoradio-resistance colorectal cancer cell model and its changes in biological behavior
Shan Liu, Zeng Zhang, Qian An, Yue Jia, Qin Su, Dezhi Zhu, Likun Luan, Hongying Yang, Zhirui Chuan, Xinyuan Liu, Siyu Wang, Yanyan Liu, Fenglian Fu, Qiong Sun, Luyao Ma, Juanrong Yang, Yiming Zhang, Mingzhi Duan, Peijun Yao, Changqing Yang, Yiming Xing, Hongmei Shen, Yongxin Jiang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:241
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 (31 August 2026) 
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Prediction of histological response by PET-CT after 2 weeks of neoadjuvant chemo-radiotherapy for rectal cancer: a prospective clinical trial
Daniel Reinhorn, Yulia Kundel, Noa Gordon, Judit Prus, Sara Morgenstern, Nir Wasserberg, David Groshar, Hanna Bernstine, Baruch Brenner
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:242
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 (31 August 2026) 
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Landscape of acquired resistance alterations in gastrointestinal malignancies after genomically targeted therapy
Priyadarshini Pathak, Bennett Caughey, Haley Barnes, Matthew Strickland, Elizabeth Walsh, Jeffrey Clark, Lawrence Blazkowsky, Aparna Parikh, Colin Weekes, Samuel Klempner, Ryan Corcoran
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:243
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 (31 August 2026) 
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Development and preliminary validation of plasma cell-free DNA methylation-based diagnostic prediction model for colorectal cancer detection
Ying Qu, Runheng Huang, Yaqing Chen, Peng Xia, Bin Huang, Jie Liu, Lingxiang Wu, Ruohan Zhang, Qianghu Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:244
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 (31 August 2026) 
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Second-line raltitrexed plus irinotecan (SALIRI) with bevacizumab, cetuximab, or alone for metastatic colorectal cancer: a prospective multicenter cohort-based secondary analysis of the SALLY trial
Furong Kou, Xicheng Wang, Jian Li, Zhenghang Wang, Ting Xu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:245
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 (31 August 2026) 
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Application value of dual-phase cone-beam computed tomography during hepatic arteriography in the detection of ≤2 cm hypervascular hepatocellular carcinoma and its feeding arteries
Ruihang Wang, Jingqi Qu, Wenyan Liu, Tao Wu, Wei Han, Shengjuan Yao
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:246
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 (31 August 2026) 
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Development and validation of a novel nomogram for predicting long-term survival in gallbladder cancer: a large population-based study using the SEER database
Hao Song, Zuo-Biao Li, Qin-Wen Tai, Jun Lyu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:247
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 (31 August 2026) 
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Development and validation of prognostic nomograms for intrahepatic cholangiocarcinoma with concomitant hepatolithiasis after radical resection
Jia Li, Xiao-Hui Wang, Yi Liu, Wei Chen, Xian-Hai Mao, Jia-Hua Yao, Hao Xie, He-Ping Kan
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:248
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 (31 August 2026) 
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Metabolic burden but not metabolic dysfunction-associated steatotic liver disease affects the prognosis of patients with hepatocellular carcinoma after hepatectomy: a retrospective cohort study
Ming Zhang, Zhan-Cheng Qiu, Jun-Long Dai, Tian-Fu Wen, Chuan Li
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:249
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 (31 August 2026) 
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Global impact of hepatitis B vaccination on the risk of hepatocellular carcinoma: a systematic review and meta-analysis
Jingyao Wang, Jie Xu, Juan Meng, Xiaoyang Shi, Shichao Geng, Xiaolan Wang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:250
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 (31 August 2026) 
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Immunological characteristics of calmodulin-related genes in hepatocellular carcinoma and their potential for prognostic prediction and diagnostic applications
Wenjia Wei, Shuangling Ni, Luxiang Liu, Siqin Long, Yuli Ge
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:251
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 (31 August 2026) 
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Comparison of the efficacy of transarterial chemoembolization combined with different molecular targeted agents and/or immune checkpoint inhibitors for unresectable hepatocellular carcinoma: a systematic review and network meta-analysis
Jia-Ye Long, Xin-Hong Wang, Yong-Run Li, Shang-Ren Huang, Zhi-Jian Li, Yan Luo
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:252
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 (31 August 2026) 
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Relationships among slow diffusion coefficient and diffusion-derived ‘vessel density’ signal features, Gadoxetate delayed enhancement, tumor size, tumor grading, and patient survival: an exploratory study of mass-forming intrahepatic cholangiocarcinoma
Cun-Jing Zheng, Fan-Yi Xu, Xiao-Hui Duan, Wen-Ting Zeng, Ming-Hua Sun, Jun Shen, Yì Xiáng J. Wáng
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:253
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 (31 August 2026) 
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Construction of molecular signatures based on the co-expression network of NECSO-related gene TRPM4 and its prognostic value in hepatocellular carcinoma
Junze Chen, Jiamei Li, Zhiyong Lin, Cheng Zhang, Yongyuan Jian, Kaiyong Huang, Ruiling Su, Xuelin Tan, Xianxiang Chen, Mei Yao
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:254
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 (31 August 2026) 
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Organ-specific response to atezolizumab + bevacizumab combination therapy for unresectable hepatocellular carcinoma with extrahepatic metastases: a retrospective cohort study
Akihiro Dejima, Kuniaki Arai, Tomoyoshi Chiba, Hidenori Kido, Noboru Takada, Takeshi Terashima, Tatsuya Yamashita, Taro Yamashita
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:255
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 (31 August 2026) 
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A practical nomogram for predicting survival in patients with extrahepatic cholangiocarcinoma: a population-based cohort study
Guanjun Zhang, Yaqi Zhai, Ke Meng, Yuting Han, Shengxin Chen, Mingyang Li
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:256
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 (31 August 2026) 
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SLC25A45 as a prognostic biomarker promotes malignant progression via mutant p53 in hepatocellular carcinoma
Kang Li, Yuqiao Shen, Pengfei Wei, Xin Geng, Lunkai Huang, Cijun Peng, Yong Mei
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:257
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 (31 August 2026) 
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A novel glutamine metabolism-based classification system for characterizing the heterogeneity of hepatocellular carcinoma
Meijun Li, Zhiyi Chen, Xudong Shen, Zhenyu Feng, Shaohua Wei, Yecheng Li, Minjian Zhang, Zhenyu Ye
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:258
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 (31 August 2026) 
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A CFH- and SPINT2-based prognostic signature for cholangiocarcinoma
Sen Chen, Weiyang Ma, Beiqi Li, Jie Zhang, Wenxi Xie
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:259
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 (31 August 2026) 
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Evolving burden of pancreatic cancer in the Middle East and North Africa Region, 1990–2023: an analysis based on the Global Burden of Disease Study 2023
Emad Aljohani, Abdullah Albarrak, Badr F. Al-Khateeb, Noof Alwatban, Khadijah Angawi, Maryam Alhabas, Raed Aldahash, Amani Alharthy, Abdullah T. Alanazi, Ashraf El-Metwally
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:260
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 (31 August 2026) 
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Association between preoperative statin use and survival after pylorus-preserving pancreaticoduodenectomy for pancreatic or periampullary cancer: a propensity score-matched cohort study
Chan-Sik Kim, Yeon-Ju Kim, Namho Kim, Hyeong-Seok Yoon, Young-Ki Kim, Eun-Kyung Ryu, Ji-Hoon Sim, Sung-Moon Jeong
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:261
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 (31 August 2026) 
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Development and validation of a nomogram based on three-dimensional quantitative parameters from dual-layer detector spectral computed tomography for predicting treatment response to neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma
Ya Zou, Xinwei Wang, Zuhua Song, Dan Zhang, Zhuoyue Tang
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:262
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 (31 August 2026) 
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Review Article

Chronic psychological stress and gastric cancer: bidirectional associations, biological mechanisms, and clinical implications—a narrative review
Lingran Zhao, Longjun Yang, Ninghui Zhao, Qiang Ding, Panpan Lu, Xinxia Feng, Mei Liu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:263
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 (31 August 2026) 
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MNAT1 in gastrointestinal cancers: mechanistic insights and therapeutic strategies—a narrative review
Yanhua Zhang, Aiqi Hu, Chun Wen, Xi Yang, Xiaopai Wang, Sanping Zheng
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:264
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 (31 August 2026) 
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Impacts of neoadjuvant therapy on subsequent surgical difficulty, safety, and outcomes in locally advanced rectal cancer: a narrative review
Zhibo Tan, Jiazuo Cai, Lufan Tang, Junjie Liao, Jiankun Liu, Zhengming Guo, Tiemin Zhang, Jiade Jay Lu
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:265
.
 (31 August 2026) 
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From clinical insight to trial design: advancing circulating tumor DNA-informed care in pancreatic cancer
Benjamin Ascherman, Daniel King
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:266
.
 (31 August 2026) 
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Study Protocol

Hepatic arterial infusion or intravenous infusion of adebrelimab, combined with bevacizumab and HAIC of the FOLFOX regimen for advanced unresectable hepatocellular carcinoma (HAIBrave-001 trial): a study protocol of a prospective, double-arm, phase II trial
Lujun Shen, Letao Lin, Yujie Zhang, Xiaoqiang Fang, Huijuan Lan, Weijun Fan
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:267
.
 (31 August 2026) 
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Case Report

Neuroendocrine tumors of unknown primary: a case report and review of tumors with gastroenteropancreatic features
Kimiya Ghassemzadeh, Josephine E. Chang, Reed I. Ayabe, Oliver S. Eng
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:268
.
 (31 August 2026) 
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Brief Report

Diagnostic biopsy-to-treatment interval and risk of recurrence in localized pancreatic ductal adenocarcinoma: every week counts
Marisa Siebel, Meredith Akerman, Austin Siebel, Neha Puttagunta, Naveena Chittineedi, Anthony Coelho, Bhupesh Parashar
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:269
.
 (31 August 2026) 
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Non-operative management of rectal adenocarcinoma in a safety-net system: a decade of real-world outcomes outside watch-and-wait eligibility
Ashley N. Chavana, Piyush Pathak, Caleb Stewart, Laurynn Garcia, Alfredo Echeverria, Eric Silberfein, Cary Hsu, Benjamin Musher, Alexander N. Hanania
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:270
.
 (31 August 2026) 
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Association of ctDNA RAS mutational status and clinical benefits in first-line metastatic colorectal cancer therapy with chemotherapy plus anti-EGFR (overall response rate and progression-free survival): a brief report of systematic review and meta-analysis
Manuel Valladares-Ayerbes, Pilar García Alfonso, Volker Heinemann, Paolo Manca, Sebastian Stintzing, Filipo Pietrantonio, Clara Montagut, Maria José Safont Aguilera, Joan Maurel, Encarna González Flores, Joana Vidal, Vincenzo Formica, Montse Sabaté-Pina, Verónica Alfonso-González, Gerard Prat-Llorens
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:271
.
 (31 August 2026) 
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Letter to the Editor

Prognostic role of resting heart rate in patients with colorectal cancer
Wonhee Cho, Dong Hoon Lee, Nam-Kyu Kim, Justin Y. Jeon
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:272
.
 (31 August 2026) 
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DNA-dependent protein kinase inhibition as a radiosensitizer in rectal cancer: toxicity must be evaluated in the context of organ preservation
Revathi Ravella, Wini Zambare, Diana Roth O’Brien, Paul B. Romesser
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:273
.
 (31 August 2026) 
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Editorial Commentary

Persistent FGFR pathway dependence: where does tinengotinib fit after FGFR inhibitor therapy in advanced cholangiocarcinoma?
Hideki Sasanuma, Hironori Yamaguchi
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:274
.
 (31 August 2026) 
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Optimizing hepatocellular carcinoma screening in the era of metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease: time to lower the alpha-fetoprotein threshold
Jennifer Au, Sang Hee K. Choi, Jill Lane, Gauree G. Konijeti
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:275
.
 (31 August 2026) 
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Beyond trastuzumab: redefining first-line HER2-positive gastroesophageal cancer with bispecific HER2 targeting
Rishi Bothara, Rutika Mehta
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:276
.
 (31 August 2026) 
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Identifying actionable targets: predicting imatinib nonadherence in patients with gastrointestinal stromal tumors
Lauren Janczewski
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:277
.
 (31 August 2026) 
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Therapeutic drug-monitoring-guided desensitization for severe imatinib-associated rash
Paul Stendahl Dy, Emil Lou
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:278
.
 (31 August 2026) 
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Endoscopic ultrasonography ablation for small pancreatic neuroendocrine tumors
Tanmay Srinivasan, Tamas Gonda
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:279
.
 (31 August 2026) 
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Editorial

Extending the utility of anti-EGFR therapy in metastatic colorectal cancer
Christopher Cann, Namrata Vijayvergia
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:280
.
 (31 August 2026) 
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Cadonilimab plus chemotherapy in PD-L1-low gastroesophageal cancer: a bispecific opportunity?
Sohiel Deshpande, Daniel Lin
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:281
.
 (31 August 2026) 
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Ferroptosis in gastrointestinal stromal tumors
Robert Jenke, Achim Aigner
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:282
.
 (31 August 2026) 
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Erratum

Erratum: Barcelona Clinic Liver Cancer strategy adherence in hepatocellular carcinoma and its influence on long-term outcomes
Editorial Office
Journal of Gastrointestinal Oncology  
2026;
17
(4)
:283
.
 (31 August 2026) 
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