Vol 16, No 6 (December 31, 2025): Journal of Gastrointestinal Oncology

Original Article

Development of a predictive model for lymph node metastasis in esophageal cancer using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) semi-quantitative parameters and tumor biomarkers
Nan Li, Min Huang, Wenjun Bao, Chenmin Ding, Xibao Mao
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2515-2526
.
 (31 December 2025) 
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Survival analysis of small cell carcinoma of the esophagus: a 15-year retrospective study from a high-incidence region
Wei Zhang, Jie Yuan, Baihua Yang, Jiezhong Wang, Mingqiu Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2527-2538
.
 (31 December 2025) 
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First-line PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone for advanced esophageal and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of randomized controlled trials
Sijia Ren, Xikai Zhang, Xiao Zhou, Xianyuan Miao, Qiongqiong Wang, Yefang Lao, Zhongzhong Peng, Kaifeng Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2539-2552
.
 (31 December 2025) 
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The clinical efficacy and pathological assessment of neoadjuvant imatinib treatment in patients with primary gastrointestinal stromal tumors
Chunhui Shou, Weili Yang, Xue Zhang, Xiaodong Wang, Qing Zhang, Jiren Yu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2553-2564
.
 (31 December 2025) 
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mTLS status predicts survival benefit from adjuvant chemotherapy in gastric cancer patients treated with neoadjuvant therapy and surgery
Dan Liu, Chenyu Tian, Bosen Li, Xinyou Liu, Chengbo Ji, Yihong Sun, Junjie Zhao, Haojie Li, Xuefei Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2565-2583
.
 (31 December 2025) 
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Trifluridine/tipiracil (FTD/TPI) in advanced gastric cancer—a retrospective cohort study providing real-world survival and safety data from the United Kingdom
Joseph Salf, Aimee Cunningham, Dinakshi Shah, Victoria Kunene, Sudha Karanam, Ellanna Griffin, Hannah-Leigh Gray, Harry Potts, Hebaalah Elsandoby, Hossam Abdulkhalek, James Bennett, Samuel L. Hill, Fangfei Gao, Robert Kitson, Donald McLeod, Edward Park, Martin Scott-Brown, Elizabeth Smyth, Was Mansoor, Russell D. Petty, Mark A. Baxter
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2584-2591
.
 (31 December 2025) 
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Parenteral nutrition versus enteral nutrition after gastric cancer surgery: a systematic review and meta-analysis of randomized controlled trials
Liping Yang, Lihua Yang, Ling Yang, Chao Xia, Chaonan Fei, Peibei Duan
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2592-2602
.
 (31 December 2025) 
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Trends of mortality among patients with malignant neoplasms of digestive system in the United States from 2007 to 2021
Yu Hua, Yuting Zhang, Shangcheng Yan, Yichun Zhu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2603-2612
.
 (31 December 2025) 
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The effect of neoadjuvant chemoradiotherapy on perioperative outcomes in rectal cancer patients following stoma reversal—a retrospective cohort analysis
Mary Junak, Rosemarie Turk, Mohammad Afaque Alam, Eli Thompson, David Schaub, Joseph Gunderson, Anesu S. Masango, Srikar Kollipara, Andrea Moreno, Daniom Tecle, Valentine N. Nfonsam
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2613-2619
.
 (31 December 2025) 
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The optimal number of lymph nodes examined for rectal cancer patients undergoing neoadjuvant long-course chemoradiotherapy
Kexing Xi, Lin Feng, Tianlei Xu, Lin Zhang, Yuelu Zhu, Hui Fang, Haizeng Zhang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2620-2631
.
 (31 December 2025) 
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Predicting bevacizumab efficacy: the emerging role of ACTL6B in colorectal cancer
Xia Weng, Jiyun Zhu, Xiaoshuai Zhou
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2632-2650
.
 (31 December 2025) 
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A prognostic nomogram for colorectal cancer: integrating blood microbiome and clinical factors
Hui Yang, Xiaoli Liu, Dajin Yuan, Huimin Li, Xiaofeng Mu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2651-2663
.
 (31 December 2025) 
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Bibliometric analysis on the correlation between colorectal cancer and tumor microenvironment [2009–2024]
Longjun Huang, Wenjuan He, Jian Zheng, Yong Guo, Jianzhong Gu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2664-2685
.
 (31 December 2025) 
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Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: a systematic review and meta-analysis
Jahnavi Udaikumar, Sushrut Ingawale, Rithish Nimmagadda, Satwik Kuppili, Vindhya Vasini Lella, Tarun Kumar Suvvari, Abraham Cheloff, Amulya Bellamkonda, Suprabhat Giri, Paul Oberstein, Aasma Shaukat
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2686-2702
.
 (31 December 2025) 
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ZNF454-FSTL3 axis inhibits colorectal cancer progression by inhibiting HIF-1α-mediated glycolysis in hypoxia
Pingfei Tang, Yueming Wu, Lin Tan, Chao Zhang, Liping Qin, Dajun Wu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2703-2718
.
 (31 December 2025) 
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Glutaryl-CoA dehydrogenase: a key biomarker linking lysine degradation to hepatocellular carcinoma metastasis and prognosis via NF-KB signaling pathway
Qiuhui Hu, Shizhuan Huang, Zhizhou Li, Yang Yu, Shan Yu, Dehai Wu, Sheng Tai
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2719-2730
.
 (31 December 2025) 
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Safety and efficacy of transcatheter chemoembolization combined with hepatic arterial infusion chemotherapy for unresectable primary liver cancer: a single-center prospective study
Chi Xu, Jiapeng Sun, Qiongyu Liang, Yanli Lu, Jie Pan
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2731-2740
.
 (31 December 2025) 
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Efficacy and safety of tyrosine kinase inhibitors combined with sintilimab and transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer stage B/C hepatocellular carcinoma: a pooled analysis
Gen-Lin Lu, Jin-Ming Tu, Asadullah Hussainzai, Fei Tong, Renya Jiang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2741-2749
.
 (31 December 2025) 
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Predicting the prognosis of hepatocellular carcinoma after curative resection using a nomogram based on the ratio of prealbumin to platelet distribution width
Junbei Zhu, Jianhao Huang, Qiang Wang, Kai He
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2750-2774
.
 (31 December 2025) 
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Revisiting the role of postoperative adjuvant transarterial chemoembolization in hepatocellular carcinoma: a propensity score matching analysis
Jia-Jun Li, Ye Xu, Hua-Hua Liu, Mao-Pei Chen, Yi Chen, Ning-Ling Ge, Lan Zhang, Zheng-Gang Ren, Xin-Rong Yang, Rong-Xin Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2775-2788
.
 (31 December 2025) 
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Survival outcomes of patients after liver transplantation for patients with hepatocellular carcinoma exceeding the Hangzhou criteria
Zhi-Ping Huang, Shu-Tong Lu, Jin Du, Ren-Dong Liu, Qing Ouyang, Bao Zhang, Meng-Chao Wang, Diamantis I. Tsilimigras, Hani M. Wadei, Yu-Jian Zheng, Shao-Ping Wang, Feng Huo, Xiao-Yu Tan, Jian-Xiong Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2789-2801
.
 (31 December 2025) 
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Landscape targeted of therapy in advanced pancreatic adenocarcinoma: a network meta-analysis of randomized controlled trials [2010–2024]
Huixin Ma, Sheng Wang, Yunjin Ya, Yun Jin, Shikang Deng
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2802-2813
.
 (31 December 2025) 
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Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus
Rei Takahashi, Akira Saito, Hideyo Miyato, Yuki Kimura, Yuichi Aoki, Masanobu Taguchi, Kazue Morishima, Hideyuki Ohzawa, Kazuhiro Endo, Hideki Sasanuma, Hironori Yamaguchi, Hiroshi Kawahira, Hisanaga Horie, Yoshinori Hosoya, Toshiki Mimura, Joji Kitayama, Naohiro Sata
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2814-2826
.
 (31 December 2025) 
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The value of lipid metabolism-related genes in pancreatic cancer immunotherapy and drug prediction
Runxin Xue, Zhiwei Tao, Rui Bai, Yan Shao, Na Liu, Chuying Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2827-2846
.
 (31 December 2025) 
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Lumbar centroid level subcutaneous fat volume increased performance of prognostic predictive model in digestive system cancers: a real-world cohort study
Lin Zheng, Jun-Li Zhang, Li-Li Wu, Rong-Jun Shao, Xiao-Xuan Ye, Wei-Cheng Li, Liang Zhang, Yu-Yue Zhang, Feng-Ming Zhang, Yu-Hang Ye, Xiao-Wei Le, Teng Zhang, En-Yu Wang, Rui-Zhi Ye, Guang-Xian You, Rong-Biao Ying, Ru-Xuan Yan, Zhi-Rui Zhou
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2847-2863
.
 (31 December 2025) 
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Case Report

Hypercalcemia in metastatic pancreatic neuroendocrine tumor: a case report of ectopic 1,25 hydroxyvitamin D production by tumor cells and tumor-associated macrophages
Sue Mei Lau, Ayanthi Wijewardene, Koroush Haghighi, Anthony J. Gill, Frederic Sierro
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2864-2872
.
 (31 December 2025) 
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Staged approach to overcome hyperbilirubinemia: tailored chemotherapy in liver metastases-a case report
Shadi Chamseddine, Khalil Choucair, Muhammad Wasif Saif
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2873-2880
.
 (31 December 2025) 
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Multidisciplinary team approach of treatment of a metastatic gastric carcinoma during pregnancy: a case report
Job F. H. Eijsink, Joost N. Udo, Jan Gerard Maring, Rieneke T. Lugtenberg, Helle-Brit Fiebrich
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2881-2886
.
 (31 December 2025) 
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Intraocular metastasis from an anal squamous cell carcinoma: a case report
Sameeha Sajid, Muhammad Daud Abdullah, Ammar Yousif
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2887-2890
.
 (31 December 2025) 
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Editorial

Claudin 18.2 in gastroesophageal adenocarcinoma: prevalence, biomarker associations, and implications for equity
Yassine Alami Idrissi, Alina Zatsepina, Anwaar Saeed
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2891-2894
.
 (31 December 2025) 
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Editorial Commentary

Right place right time: the role of immunotherapy in patients with locally advanced gastric/gastroesophageal junction adenocarcinoma
Abigail Fong, Dani Castillo, Pranati Shah, Sophia Guzman, Gagandeep Brar
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2895-2899
.
 (31 December 2025) 
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Potential of regorafenib in late-line treatment for refractory advanced gastric cancer
Chikara Kunisaki
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2900-2904
.
 (31 December 2025) 
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Erratum

Erratum: The clinical value of spectral computed tomography reconstruction technology for the anatomy of the superior mesenteric artery in laparoscopic radical right hemicolectomy for colon cancer: a cross-sectional study
Editorial Office
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2905-2906
.
 (31 December 2025) 
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